| | Day | Time | | Opponent | Score | | | Record |
| August |
| | 26 | 6:00PM | vs. | Point Park College | L-26-28,19-25,22-25 | recap | | 0-1 |
| | 2010 Regular Season Opener |
| | 27 | 5:00PM | vs. | Indiana University East | L-11-25,15-25,20-25 | recap | | 0-2 |
| | Aces In August Classic |
| | | 7:00PM | vs. | Martin Methodist | L-25-17,20-25,20-25,21-25 | recap | | 0-3 |
| | Aces In August Classic |
| * | 28 | 9:00AM | vs. | Cumberlands (KY) | W-23-25,23-25,25-14,25-18,15-13 | recap | | 1-3 1-0 |
| | Aces In August Classic |
| | | 11:00AM | vs. | Martin Methodist | L-17-25,9-25,25-19,22-25 | recap | | 1-4 |
| | Aces In August Classic |
| September |
| | 2 | 7:00PM | @ | Mountain State University | W-19-25,21-25,23-25 | recap | | 2-4 |
| * | 6 | 6:00PM | @ | University of Pikeville | W-16-25,13-25,22-25 | recap | | 3-4 2-0 |
| * | 15 | 6:30PM | @ | West Virginia Institute of Technology | W-17-25,19-25,12-25 | recap | | 4-4 3-0 |
| | 17 | 1:00PM | @ | Cumberland Univ. | L-25-17,25-17,15-25,25-23 | recap | | 4-5 |
| | Cumberland (TN) Tournament |
| | | 7:00PM | vs. | Trevecca Nazarene University | L-25-9,15-25,24-26,25-18,15-6 | recap | | 4-6 |
| | Cumberland (TN) Tournament |
| | 18 | 9:00AM | vs. | Bethel College | L-24-26,25-16,25-18,26-24 | recap | | 4-7 |
| | Cumberland (TN) Tournament |
| | | 3:00PM | vs. | Union University | L-25-19,25-18,25-19 | recap | | 4-8 |
| | Cumberland (TN) Tournament |
| | 21 | 6:00PM | @ | Central State University | W-9-25,18-25,9-25 | recap | | 5-8 |
| | Doubleheader - 1st match made up from September 9 |
| * | 24 | 6:00PM | vs. | UVA-Wise | W-25-15,25-11,25-14 | recap | | 6-8 4-0 |
| * | 28 | 7:00PM | vs. | Shawnee State University | L-26-24,19-25,18-25,23-25 | recap | | 6-9 4-1 |
| October |
| * | 1 | 7:00PM | vs. | St. Catharine College | W-26-24,25-16,25-19 | recap | | 7-9 5-1 |
| | 2 | 1:00PM | @ | Notre Dame College | W-25-15,13-25,17-25,24-26 | recap | | 8-9 |
| | Doubleheader |
| | | 3:00PM | @ | Notre Dame College | W-18-25,25-21,22-25,16-25 | recap | | 9-9 |
| | 7 | 6:00PM | vs. | Mountain State University | W-25-13,25-14,25-21 | recap | | 10-9 |
| | 9 | 2:00PM | @ | Mountain State University | W-12-25,23-25,14-25 | recap | | 11-9 |
| | Tri-Match |
| | | 4:00PM | vs. | Brescia University | W-11-25,13-25,15-25 | recap | | 12-9 |
| | Tri-Match |
| * | 11 | 7:00PM | vs. | Georgetown College | L-25-19,10-25,12-25,24-26 | recap | | 12-10 5-2 |
| * | 13 | 5:00PM | @ | Campbellsville University | L-27-25,25-17,25-19 | recap | | 12-11 5-3 |
| | 16 | 11:00AM | @ | Huntington University | W-25-27,29-31,15-25 | recap | | 13-11 |
| | Huntington (IN) Tournament |
| | | 1:00PM | vs. | Purdue University-North Central | W-26-24,16-25,27-29,23-25 | recap | | 14-11 |
| | Huntington (IN) Tournament |
| * | 21 | 6:00PM | vs. | University of Pikeville | W-25-15,25-15,25-13 | recap | | 15-11 6-3 |
| * | 22 | 7:00PM | vs. | Lindsey Wilson | W-25-19,25-18,25-14 | recap | | 16-11 7-3 |
| | 23 | 1:00PM | vs. | Houghton College | W-25-20,22-25,22-25,19-25 | recap | | 17-11 |
| | Tri-Match at Cedarville |
| | | 3:00PM | @ | Cedarville University | W-18-25,25-16,18-25,25-27 | recap | | 18-11 |
| | Tri-Match at Cedarville |
| * | 28 | 6:00PM | vs. | West Virginia Institute of Technology | W-25-20,25-19,25-14 | recap | | 19-11 8-3 |
| * | 30 | 10:00AM | @ | Shawnee State University | L-25-17,25-21,25-17 | recap | | 19-12 8-4 |
| | Tri-Match at Shawnee State |
| | | 12:00PM | vs. | Mount Vernon Nazarene University | L-16-25,25-22,25-21,25-15 | recap | | 19-13 |
| | Tri-Match at Shawnee State |
| November |
| * | 2 | 6:00PM | @ | UVA-Wise | W-23-25,25-22,19-25,14-25 | recap | | 20-13 9-4 |
| | 5 | 8:00PM | vs. | Malone University | W-25-23,19-25,21-25,25-23,15-10 | recap | | 21-13 |
| | 8 | 2:00PM | vs. | Cumberlands (KY) | W-24-26,16-25,25-16,17-25 | recap | | 22-13 |
| | MSC Tournament - Quarterfinal Rd. |
| | | 8:00PM | vs. | Georgetown College | L-25-13,25-9,26-24 | recap | | 22-14 |
| | MSC Tournament - Semifinal Rd. |